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Optimizing the Monitoring of Coagulation

Release Date: March 31, 2006

Expiration Date: March 31, 2007

Estimated time to complete this Activity: 45 minutes

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Overview

Thrombin generation plays a pivotal role in the mechanism of clot formation and as such is the target of several therapeutic agents. Hemostatic agents such as recombinant activated Factor VII and Factor Eight Inhibitor Bypassing Agent control hemorrhage by promoting thrombin generation, whereas anticoagulants inhibit or prevent thrombin generation that occurs in excess or at inappropriate sites. Because of the complexity of coagulation, the hemostatic effects of these agents require careful monitoring by means of coagulation tests, such as prothrombin time and activated partial thromboplastin time. However, the results of standard coagulation tests do not necessarily correspond with the pharmacokinetics of the agents and do not predict response to treatment. In this symposium, the faculty will discuss ways of optimizing the monitoring of therapies and the importance of tailoring the treatment to individual patients. In addition, the faculty will review the issues regarding monitoring patients treated with several anticoagulants.

Target Audience

Achieving Hemostasis: What Are the Optimal Monitoring and Treatment Options? is intended for hematologists and other healthcare professionals who manage individuals with congenital or acquired bleeding disorders.

Learning Objectives

After completing this CME activity, participants should be able to:

• List the limitations of standard laboratory coagulation tests in terms of monitoring coagulation
• Describe the methods used to monitor coagulation and control hemorrhage in patients being treated with several anticoagulant agents

Accreditation Statement

This activity has expired.

Designation Statement

This activity has expired.

How to Get Credit

This activity has expired.

Faculty Disclosure

It is the policy of the FCG Institute for Continuing Education that all faculty participating in continuing medical education activities are expected to disclose to the program audience (1) any real or apparent conflict(s) of interest related to the content of their presentation and (2) discussion of unlabeled or unapproved uses of drugs or medical devices. Faculty disclosure statements can be found with their biographical sketches.

Conflict of Interest Resolution

When individuals in a position to control or influence the development of the content have reported Financial Relationships with one or more commercial interests, The FCG Institute for Continuing Education utilizes a process to identify and resolve potential conflicts to ensure that the content presented is free of commercial bias. The content of this presentation was vetted through The Institute’s process of peer review and content validation and modified as required to meet this standard.

Notice About Investigational or Off-Label Use

This educational activity may include discussion of drugs or devices or uses of drugs and devices, that have not been approved by the FDA or have been approved by the FDA for specific uses only. It is the responsibility of the physician to determine the FDA clearance status of each drug or device he or she wishes to use in clinical practice. The FCG Institute for Continuing Education is committed to the free exchange of medical education. Inclusion of any product or device discussion, including discussion of investigational or off-label uses, does not imply endorsement by The Institute of the uses, products, or techniques presented.

Disclaimer

This CME/CE activity is designed for use by healthcare professionals for educational purposes only. The information and opinions expressed by the faculty are their own and do not necessarily reflect those of The FCG Institute. The FCG Institute for Continuing Education does not define a standard of care, nor does it intend to dictate an exclusive course of management but presents through the educational activities it sponsors recognized methods and techniques of clinical practice for consideration by physicians and other healthcare providers for incorporation into their practices. Participants should use their own clinical judgment before applying information, whether provided here or by others, for any professional use.

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Sponsored by: The FCG Institute for Continuing Education

The FCG Institute for Continuing Education
gratefully acknowledges an educational grant from
Novo Nordisk Inc. in support of this Web Site